Synthesis of 2,3,4,5-tetrahydro-1H-pyrrolo[1,2-a][1,4]diazepines and 11-methyl-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]indoles
نویسندگان
چکیده
منابع مشابه
Asymmetric synthesis of (7aS)-7a-methyl-4,5,7,7a-tetrahydro-1H-indene-2,6-dione and useful derivatives thereof.
The enantioselective synthesis of the title compound, using Meyers' bicyclic lactam methodology, is described. This compound and a few of its derivatives are useful intermediates in natural product synthesis.
متن کاملSynthesis and X-ray structural studies of a substituted 2,3,4,5-tetrahydro-1H-3-benzazonine and a 1,2,3,5-tetrahydro-4,3-benzoxazonine.
Using a common 1-(1-phenylethenyl)-1,2,3,4-tetrahydroisoquinoline precursor to the required ylide or N-oxide intermediate, the Stevens [2,3] and analogous Meisenheimer [2,3] sigmatropic rearrangements have been applied to afford concise syntheses of phenyl -substituted representatives of each of the reduced 1H-3-benzazonine and 4,3-benzoxazonine systems, respectively. Single crystal X-ray struc...
متن کاملSyntheses of 11-substituted 3-methyl-3,4,10,11-tetrahydro-1H,5H-pyrano[4, 3-b][1,5]benzodiazepin-1-ones.
In the course of our synthetic studies on biologically active compounds using dimedone, tetronic acids, and tetramic acids,1) we reported that some 10-substituted 3,3-dimethyl3, 4, 9, 10tetrahydro1Hfuroand -pyrrolo [4, 3-b] [1, 5] benzodiazepin1-ones (1 and 2) showed analgesic activity as strong as that of aminopyrine in the phenylquinone writhing test in mice.2) Namely, the extents of inhibiti...
متن کاملExperimental and Theoretical Studies on a Derivative of Tetrahydro-1H-Benzodiazepine
N-Cyclohexyl-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,5]diazepine-2-carboxamide (5) was synthesized using an efficient, highly recyclable and eco-friendly catalyst heteropolyacid/triethoxysilyl)propyl]isonicotinamide (HPA/TPI-Fe3O4 nanoparticles) in one-pot. The compound 5 was characterized by FT-IR,1H NMR, 13C NMR, mass spectra, and elemental analysis. The theoretical calculations on 5...
متن کامل2,3,4,7-Tetrahydro-1H -inden-2-ol: synthesis, molecular structure and coordination chemistry
2,3,4,7-Tetrahydro-1H -inden-2-ol (1) has been synthesised by Birch reduction of indan-2-ol. A single-crystal X-ray structur analysis of 1 shows the compound to exist as hydrogen-bonded polymers along the c-axis due to the presence of a series of hydrogen bonds between hydroxo functions. The ferrocene ester derivatives, ferrocene carboxylic acid 2,3,4,7-tetrahydro-1H -inden-2-yl este (2) and fe...
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ژورنال
عنوان ژورنال: Arkivoc
سال: 2003
ISSN: 1551-7012
DOI: 10.3998/ark.5550190.0004.902